722621. The base pair of cg00116234 was 18464243. This DMS

ed at the zero degree, i.e., at the right end. Although four spectra

me difference, obviously many remote DEGs had their differential

n pattern greatly impacted on the differential methylation of

234. In other words, the differential methylation status of

234 was mainly contributed or determined by the differential

ns of many remote DEGs.

es 4.40(a) and (b) show a Lasso model and a RLR model for the

00116234. In the Lasso model, the closest distance between a

h a high-ranking score and cg00116234 was about 1.4 mega bases

e top-ranked genes. The maximum distance was about 42 mega

the RLR model, the closest distance was about 1.6 mega bases

e top-ranked genes while the maximum distance was about 100

es away.

(a) (b)

Two models for the DMS cg00116234. The legends show the base pair of the

n site of the DMS. The figures printed in the plots stand for the mean base pairs

anked DEGs. (a) The Lasso model. (b) The RLR model.

y

pter has introduced regression analysis algorithms, which can be

he genetic-epigenetic interplay pattern discovery. In this kind of

the first objective is to discover how the genetic signatures and